I think a lot of times your defense depends on your opponent's tendency. Look for signs of who is their go-to player and their 2- and 3-man. Next look to figure out what your opponent's tendency is by looking at box scores, aiming particularly at their frequency of 3-pt attempts and 2-pt attempts. Any 3-pt attempts in roughly the 30-40% range indicates that their primary shooter is likely one of their wingmen or their guards.
Second, look at a few game replays where you opponent played Patient and go to the last second of the game where it ends and take a few mental notes of where the primary two-pointers are being shot at. If most of their 2-pointers appear to be near the 3-point line, playing a 3-2 would work. If their 2-pointers tend to be near the paint, then playing a 2-3 would be fine as well.
Obviously, if the Center and/or Power Forward are the most frequent shooters, then focus on interior defense. However, if their guards or wingmen are attempting the most shots, knowing where the two-pointers are being attempted at would help you decide which defense.
Anyways, that's how I tend to game plan. It works a lot of times but not always.