From what I've seen they work in reverse. Outside Iso, brings double teams to those players, so they pass it off to Inside guys. Inside Iso, double team, pass off to the Outside.
If your 4-5 can handle & pass try that, if they can't do Outside Iso. Both of these systems are Base Offense orientated though. If there is a weakness at the 4, then I'd play Look Inside, it's the favourite offense for a reason ;)
Right is not a popularity contest!