I don't know for sure what would give problems as far as offense goes. I am a long way from having the team in place that will be successful in Princeton. My current center is not built for it, he is a place holder until I develop one to take over. I just sold my sg who was built pretty well for it, but had a couple flaws. The placeholder I have at SG is not built at all for Princeton. All of that being said, the dynamics of the inside/out offense is really intriguing. You will post significant game ratings in outside scoring. This would lure teams into playing a 3-2. I think 3-2 against a well built Princeton team is a mistake. When the flow is correct your guards get 5-8 ft jumpers near the basket and your bigs and sf will take 12 footers. All presumably in the soft spots in the zone. These are all really guesses but fairly educated. I have played it enough and even watched teams at higher levels games. You can see when mismatches are exploited and I think you just have to sell out your builds to make it work. I think Manon has a really good handle on how to build it.
I don't think there are specific offenses that would give the offense issues because I don't think the GE operates that way. I don't think one offense puts your team in a position to not get back well on defense compared to others. It should but I don't think it does. I think LI should have difficulty getting back on defense against RNG teams or other LI teams, faster paced. It would make sense, since the offensive guys are attacking the basket and I don't believe it is in the form of an iso clear out. The offense to stop is LI but not because of the style of offense you play. LI is the easiest, mindless to build offense out there. Granted there are well built LI teams, but even bad ones, if you throw enough cash at them, are mildly successful. The TL is full of players that are successful in this offense. The issue is the rebounding advantage obtained by running LI. To combat that, I believe your Princeton PF and Center will need to sacrifice IS for Reb. It would also be wise to have significant rebounding on your SF. I have seen some upper level teams stipulate that high JR is required to run Princeton. I think team passing is way more important, and if you implement a high level of passing, the offense runs completely different than if you plug your RNG team in offense. A good RNG team gives the appearance of jacking up three point shots at an incredibly slow pace when running Princeton. Add passing, and that all changes. It becomes a methodical attack on the weakness in the defense.
These are just my thoughts. I have no hard core data or proof it will work. I just have to take the BB's word that the game is not broken and everything is on even keel. I really enjoy the game, but my goals are different than most. If I never make the NBBA, that is ok with me. I would rather explore the unknown and break the mold. I haven't seen many teams at the highest level run Princeton successfully, at least not in large countries.