Against that high defense I think most offenses have trouble.
That's true but flow is a team's rating not individual only, so provided that you have decent passing spread out among your players, you might have a decent and 'reasonable' shot distribution in LI/PTB/Princeton pretty much any 'focused' tactic. In ISOs, if I'm understanding correctly, if the go-to guy can't overpower his defender you're toast, much like in Patient, except in Patient the designated scorer will just try to score and in ISOs he can also create for others (so he has more options).