I agree with E.B.W., it is absolutely possible to start twice a week your best players if the subs are good enough. Except possibly the trainees since we expect them to play a full game at 48 minutes already.
If starting equals 30mpg, then it is possible.
Players like Gortat average those minutes... Top players are around 36-38 mpg, which would hurt your gameshape longterm.
Maybe something like a three week rolling average could be a possible solution, so that you could bench your players (like the Spurs do it) in games that can be thrown or where the opponent is too weak.
Größter Knecht aller Zeiten aka His Excellency aka President for Life aka Field Marshal Al Hadji aka Lord of All the Beasts of the Earth and Fishes of the Seas aka aka Conqueror of the Buzzerbeater Empire in Europe in General and Austria in Particular