I don't know Jason. Me First has only used worst two defenses in BB that I could see (2-3 and FCP). Have him play a real defense and his lackluster defensive ratings become more....luster. And Me First has something rare in D4, awesome depth.
Well, let me give you an example....
(26257792) I was working with this other team for a bit helping him out until he drove me insane from his crazy illogical questions. This team (prior to me offering him any help), trained nothing but OD for 2 seasons. As a result, he has some very strong OD, but at the time of this game, he had absolutely no offensive weapons at all. To me this illustrates how a team with a great defense can slow down a team like Me First. Understand, this other team didnt just have a below average offense, he had a horrific offense! So a team with a solid defense would absolutely slow Me First down, and if that team can score too, I think it would be enough to get over the top against them.