Nothing is guaranteed but :
1. Put him as Starter/Backup?Reserve
2. Use Strictly Follow Depth Chart
3. Use Let them Play
4. Make sure there is no one one the bench to replace them in a blowout. For example if u want your centre to play a whole game only have 4 players on the bench, your backup PG, SG, SF and PF. So u only play the game with 9 players
5. If the player is fouled out or injured you just have to cop it theres a risk in playing a guy 48 minutes u just have to be willing to accept it.