It seems to me that you absolutely need big men with good passing. The guards will pass it inside, but the big man is often double teamed so he passes it back out. When I use it, I notice a lot of passes from my star big man back to the point guard who drives for a layup, or a pass to my shooting guard who shoots a 3 pointer.
I have a balanced roster, and notice that my team shoots (and makes) a lot more 3 pointers with Inside Isolation than with Look Inside or Low Post.