Wouldn't a 3-2 zone be better (if you have the right players) to defend against Patient, especially if the opponent uses the strategy of playing a 3pt shooter at C? That way you're sure you're best outside defenders actually defend the outside, instead of having your C defend the perimeter.
Patient offense is used to exploit the best mismatch you have vs the other team, period.
When one plays a zone, the player on offense shoots (usually) against the weakest defender in the zone. So in a 3-2 the inside guy with lower ID gets shot on more, the Outside guy with lower OD gets shot on more. As a result, if they are out of their league, they tend to foul more, and foul out quicker, thus putting in your bench players, whom are even worse defensively.
By playing man to man, not only do you know whom is guarding whom and who will shoot etc. but there are no surprises on who the opposition has that will be shooting/attempting to score on you. Doing it in this such manner, makes it predictable, and easier to counter.
Also, just because my PG is playing C and shooting 3s... doesn't mean my PG isn't playing PG...
Personally I think Patient offense is a choice you make when you are tanking, or trying to win an mvp award.