On defense Player 1 @ C and Player 2 @ PF due to ID and REB (although 1's OD is slightly better than 2's).
On offense, I'd speculate your opponents strengths & weaknesses. Most of PF's have decent OD and not so big ID (for big guys), and many C's have bottom OD and strong IDs, so it could be worthwhile to have Player 1 at PF and Player 2 at C to get some extra points. But I think it depends on the opponent. Fortunately for you, they have good PA and EXP to avoid some unwanted shots.