I think it works like this:
Driving - Insight of creating a chance for the player themselfs, going past you're opponnent
Handling - Controlling the ball, which is needed when driving, but also when receiving a pass and I think also when rebounding. I see handling as a ability which strengthens other abilities.
if you're going for a rebound, but can't control a ball, than the rebounding ability is less helpful.
The same goes for receiving a pass, it is less likely there will be a pass if you can't handle a ball
When having inside players, in a passing game the handling will be more important, when they have to create their own chance, the driving will be more important.
But that's all my theory, can't bring in any hard proof.