Well, your coach removes your players at the end of a blowout to prevent injuries. A technique that works well most of the time is to only keep on the active roster the players that are starting and the players that are playing backup.
For example, if you wanted two players to get 48 minutes, you would only field 8 players, 5 starters, and 3 subs not at the PF/C positions.
Hope this helps =]