Just look at my team that swept the finals. We were on the top defensive teams all season, ended up in 3rd place behind two loaded 20-2 teams. I put my best defenders on their studs and they couldn't do anything.
I literally guessed completely wrong on the GDP (I set up for LI and they played Patient) and they still lost (only by 2 mind you) cause my locked perimeter guys. 15 blocks in the second game didn't hurt either.