Since there's already an option to choose "Depth Chart until 4th" in game tactics. Instead of relying on your coach to decide what would be best for your team in the 4th, why not allow the option to set the actual player rotation for the 4th quarter? Perhaps even for every separate quarter.
If you want to do that you set your rotation and select 'Strictly follow depth chart'.
As far as I am concerned, the simpler this is the better.
"I don't know half of you half as well as I should like; and I like less than half of you half as well as you deserve."