Have had the best luck with not setting any reserves and ensuring that each of the non-48 min starters has their own separate backup:
P1 - P1
P2 - P6
P3 - P7
P4 - P8
P5 - P9
Any time i set reserves is seems to mess things up, esp when you have a center playing PG, or PG playing C (someone way out of position).
I still think its a bug when in the last min or so, after 46-47 mins of everything going perfect, the GE decides to sub someone like P1 out of the game. It'd make more sense if it did it when it went to blowout, but after up to 10-11 mins of blowout and then sub, that makes no rational sense.
"Well, no ones gonna top that." - http://tinyurl.com/noigttt