Depends really what you're looking for, but the last few seasons I haven't had a specific need when I've drafted so I look for On Ball Defence. OD and SB are important to me so knowing those is a big help.
If I specifically wanted a guard I think I'd consider Extra Pass, otherwise I'd stick with OD and SB if I wanted to draft a big. I don't really want to spend a long time training OD on a big so the higher the better.