I've benn doing that the whole season until a week or so ago, because I sol one player ;)
It is hard but not impossible. Try, having some decent stamina -at least 5- putting the same player in all the available spots for a certain position then use your preferences all game long.
Possible trouble, fouls. If one of your players makes no too many fouls, you're going to have some several issues.
That was until the new changes... but I think now everything is going to change, because now you may choose to not to take away your players when having foul troubles but the idea of switching positions finding some "optimun"... I'm sure it's a about to be a big trouble.