I have tried that once. I was too confident in the win and put my 8k center as a starter with 44k center as a reserve and backup (44k center didn't need that many minutes).
44k center ended up playing 13 minutes, I lost by 1 point in last second against a team I already beat on take it easy once, stayed out of playoffs and lost a bunch of money. Of course I should set "Follow chart until 4th quarter", but I didn't. I learned a lot from that.