Defensively it seems best to just man them up if you have the ability to rebound with them. If you don't then 2-3 would be necessary.
The other side of defense is offense. Can you run them off the court with a fast pace attack? They look deep with 3 Bigs and 2 SFs so maybe not. Then the flip side is slow the game down on your side, limit their possessions and keep your players fresher for the defensive side of the ball.