If it suggests run and gun and your bigs both have even decent jump shooting skills I think that would be a good idea. It is hard to make an accurate suggestion however because I cannot see all your players skills. Pretty much it comes down to this:
Look inside gets your SF and PF the majority of the shots followed by the Center and SG and then the PG.
Run and Gun gets your SG and PG the most shots normally followed by the SF and then the PF and Center.
I believe if the matchup predictor suggest run and gun though, then you should follow that and see how it works and then you can change tactics later if you do not like it. BTW Motion is very similar to run and gun except it takes more 2 point jumpers and run and gun is more 3 point jumpers so if your team doesn't have very good jump range then you could look at motion as well. Many options haha.
Murray/Harris/MPJ/Grant/Jokic - 2020 NBA Champs